Synthesis and bronchodilating activity of 2,9-disubstituted adenine derivatives: BB-1502 (9-cyclohexy-2-n-propoxy-9H-adenine) and its analogs.
نویسندگان
چکیده
منابع مشابه
THE ROLE OF CHLOROMETHYL ETHERS IN THE FORMATION OF N(7) - AND N(9)-ALKYLATED ISOMERS OF ADENINE SYNTHESIS OF 2-[9-(ETHOXYMETHYL) ADENYL] PHOSPHONATE
The structural features of chloromethyl ethers are shown to have a significant effect on the formation of N(7)- or N(9)- alkylated isomers of purine acyclo-nucleosides. The chemical synthesis of 2-[9-(ethoxymethyl) adenyl] phosphonate is described. This compound is active against herpesviruses.
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We report herein the synthesis and characterization of 9-(2-diallylaminoethyl) adenine. We evaluated two different synthetic routes starting with adenine where the optimal route was achieved through coupling of 9-(2-chloroethyl)adenine with diallylamine. The cyclopolymerization and cyclo-copolymerization of 9-(2-diallylaminoethyl)adenine hydrochloride salt resulted in low molecular weight oligo...
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The conformationally restricted adenine nucleotide analogs 8,3'anhydro-8-oxy-9-(beta-D-xylofuranosyl)adenine-5'-O-tri(di)-phosphate (I), and 8,2'-anhydro-8-oxy-9-(beta-D-arabinofuranosyl) adenine-5'-O-tri(di)-phosphate (II), were prepared chemically as their alpha-32P-labelled compounds and compared with syn-structured 8-bromo AT(D)P in mitochondrial adenine nucleotide translocation. The experi...
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By mono esterification o f 3'(2')-hydroxyl residues o f adenine nucleotides with various carboxylic acids a series o f nucleotide analogs is available including fluorescent and photoaffinity labels. Their chemical synthesis is described. The equilibrium between 2' and 3' esters is determined by NM R spectroscopy, stability o f the esters and their tendency o f acyl migration is discussed. The i...
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The synthesis of the title compound, bitamycin, by means of BU4NF is described. This new antiviral drug was found to be one of the most powerful and least toxic substances for antiviral therapy in man. The physical and chemical behavior as well as the antiviral activities and clinical properties of this compound were found to be significantly different from that reported by Schaeffer, et a...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1982
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.30.2011